284 Cancer risk among tetrafluoroethylene (TFE) synthesis and polymerisation workers
Identifieur interne : 002B87 ( Main/Corpus ); précédent : 002B86; suivant : 002B88284 Cancer risk among tetrafluoroethylene (TFE) synthesis and polymerisation workers
Auteurs : D C Consonni ; Straif ; Symons ; Tomenson ; Amelsvoort Van ; Sleeuwenhoek ; Cherrie ; Bonetti ; Colombo ; Farrar ; Carugno ; BertazziSource :
- Occupational and Environmental Medicine [ 1351-0711 ] ; 2013-09.
Abstract
Objectives Tetrafluoroethylene (TFE), a compound used for the production of fluorinated polymers including polytetrafluoroethylene (PTFE), increases liver and kidney cancer and leukaemia incidence in rats and mice. This is the first time the cancer risk in humans is comprehensively explored in a cohort mortality study. Methods The study included all current PTFE production sites in Europe (Germany, Italy, The Netherlands and UK) and USA (New Jersey and West Virginia). The study cohort included workers ever employed in the period 1950–2002. A job-exposure matrix (1950–2002) was developed for TFE and ammonium perfluoro-octanoate (APFO), a chemical used in the polymerisation process. For each worker we calculated cumulative exposure to TFE and APFO. The mortality ascertainment covered the period 1950–2008. Standardised mortality ratios (SMR) and 95% confidence intervals (CI) were calculated using national mortality rates as reference. Results Among 4,773 workers ever exposed to TFE, we found lower SMRs from most causes of death and increased SMRs for cancer of the liver (SMR 1.27; 95% CI: 0.55, 2.51; 8 deaths) and kidney (SMR 1.44; 95% CI: 0.69, 2.65; 10 deaths), and for leukaemia (SMR 1.48; 95% CI: 0.77, 2.59; 12 deaths). A non-significant upward trend (P = 0.24) by cumulative exposure to TFE was observed for liver cancer. TFE and APFO exposures were highly correlated, therefore their separate effects could not be disentangled. Conclusions The pattern of findings in this large study substantially narrows the range of uncertainty on the possible cancer risk entailed by working in TFE synthesis and polymerisation, and justifies continuing efforts to minimise exposure, which has already dropped considerably over the years. However, the findings could neither conclusively confirm nor refute the hypothesis that TFE poses a carcinogenic risk to human beings. If a cancer hazard exists, then the risk is small, even in workers with relatively high exposure.
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DOI: 10.1136/oemed-2013-101717.284
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">284 Cancer risk among tetrafluoroethylene (TFE) synthesis and polymerisation workers</title><author><name sortKey="Consonni, D C" sort="Consonni, D C" uniqKey="Consonni D" first="D C" last="Consonni">D C Consonni</name><affiliation><mods:affiliation>Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Straif" sort="Straif" uniqKey="Straif" last="Straif">Straif</name><affiliation><mods:affiliation>International Agency for Research on Cancer, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Symons" sort="Symons" uniqKey="Symons" last="Symons">Symons</name><affiliation><mods:affiliation>DuPont Epidemiology Program, E. I. du Pont de Nemours and Company, Newark, DE, United States of America</mods:affiliation></affiliation></author><author><name sortKey="Tomenson" sort="Tomenson" uniqKey="Tomenson" last="Tomenson">Tomenson</name><affiliation><mods:affiliation>Causation Ltd, Macclesfield, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Van, Amelsvoort" sort="Van, Amelsvoort" uniqKey="Van A" first="Amelsvoort" last="Van">Amelsvoort Van</name><affiliation><mods:affiliation>University of Maastricht, CAPHRI, Maastricht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Sleeuwenhoek" sort="Sleeuwenhoek" uniqKey="Sleeuwenhoek" last="Sleeuwenhoek">Sleeuwenhoek</name><affiliation><mods:affiliation>Institute of Occupational Medicine, Edinburgh, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Cherrie" sort="Cherrie" uniqKey="Cherrie" last="Cherrie">Cherrie</name><affiliation><mods:affiliation>Institute of Occupational Medicine, Edinburgh, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Bonetti" sort="Bonetti" uniqKey="Bonetti" last="Bonetti">Bonetti</name><affiliation><mods:affiliation>Solvay Specialty Polymers Italy SpA, Bollate, Italy</mods:affiliation></affiliation></author><author><name sortKey="Colombo" sort="Colombo" uniqKey="Colombo" last="Colombo">Colombo</name><affiliation><mods:affiliation>Solvay Specialty Polymers Italy SpA, Bollate, Italy</mods:affiliation></affiliation></author><author><name sortKey="Farrar" sort="Farrar" uniqKey="Farrar" last="Farrar">Farrar</name><affiliation><mods:affiliation>CCERT Ltd for Asahi Glass Company Chemicals Europe (AGCCE), Congleton, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Carugno" sort="Carugno" uniqKey="Carugno" last="Carugno">Carugno</name><affiliation><mods:affiliation>DISCCO, Università degli Studi di Milano, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bertazzi" sort="Bertazzi" uniqKey="Bertazzi" last="Bertazzi">Bertazzi</name><affiliation><mods:affiliation>DISCCO, Università degli Studi di Milano, Milano, Italy</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A15CAF5069534A577266DC3F2E4F0284A12F47AB</idno><date when="2013" year="2013">2013</date><idno type="doi">10.1136/oemed-2013-101717.284</idno><idno type="url">https://api.istex.fr/document/A15CAF5069534A577266DC3F2E4F0284A12F47AB/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002B87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">284 Cancer risk among tetrafluoroethylene (TFE) synthesis and polymerisation workers</title><author><name sortKey="Consonni, D C" sort="Consonni, D C" uniqKey="Consonni D" first="D C" last="Consonni">D C Consonni</name><affiliation><mods:affiliation>Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, Italy</mods:affiliation></affiliation></author><author><name sortKey="Straif" sort="Straif" uniqKey="Straif" last="Straif">Straif</name><affiliation><mods:affiliation>International Agency for Research on Cancer, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Symons" sort="Symons" uniqKey="Symons" last="Symons">Symons</name><affiliation><mods:affiliation>DuPont Epidemiology Program, E. I. du Pont de Nemours and Company, Newark, DE, United States of America</mods:affiliation></affiliation></author><author><name sortKey="Tomenson" sort="Tomenson" uniqKey="Tomenson" last="Tomenson">Tomenson</name><affiliation><mods:affiliation>Causation Ltd, Macclesfield, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Van, Amelsvoort" sort="Van, Amelsvoort" uniqKey="Van A" first="Amelsvoort" last="Van">Amelsvoort Van</name><affiliation><mods:affiliation>University of Maastricht, CAPHRI, Maastricht, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Sleeuwenhoek" sort="Sleeuwenhoek" uniqKey="Sleeuwenhoek" last="Sleeuwenhoek">Sleeuwenhoek</name><affiliation><mods:affiliation>Institute of Occupational Medicine, Edinburgh, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Cherrie" sort="Cherrie" uniqKey="Cherrie" last="Cherrie">Cherrie</name><affiliation><mods:affiliation>Institute of Occupational Medicine, Edinburgh, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Bonetti" sort="Bonetti" uniqKey="Bonetti" last="Bonetti">Bonetti</name><affiliation><mods:affiliation>Solvay Specialty Polymers Italy SpA, Bollate, Italy</mods:affiliation></affiliation></author><author><name sortKey="Colombo" sort="Colombo" uniqKey="Colombo" last="Colombo">Colombo</name><affiliation><mods:affiliation>Solvay Specialty Polymers Italy SpA, Bollate, Italy</mods:affiliation></affiliation></author><author><name sortKey="Farrar" sort="Farrar" uniqKey="Farrar" last="Farrar">Farrar</name><affiliation><mods:affiliation>CCERT Ltd for Asahi Glass Company Chemicals Europe (AGCCE), Congleton, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Carugno" sort="Carugno" uniqKey="Carugno" last="Carugno">Carugno</name><affiliation><mods:affiliation>DISCCO, Università degli Studi di Milano, Milano, Italy</mods:affiliation></affiliation></author><author><name sortKey="Bertazzi" sort="Bertazzi" uniqKey="Bertazzi" last="Bertazzi">Bertazzi</name><affiliation><mods:affiliation>DISCCO, Università degli Studi di Milano, Milano, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Occupational and Environmental Medicine</title><title level="j" type="abbrev">Occup Environ Med</title><idno type="ISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-09">2013-09</date><biblScope unit="volume">70</biblScope><biblScope unit="issue">Suppl 1</biblScope><biblScope unit="page" from="A96">A96</biblScope></imprint><idno type="ISSN">1351-0711</idno></series><idno type="istex">A15CAF5069534A577266DC3F2E4F0284A12F47AB</idno><idno type="DOI">10.1136/oemed-2013-101717.284</idno><idno type="href">oemed-70-A96-3.pdf</idno><idno type="ArticleID">oemed-2013-101717.284</idno><idno type="local">oemed;70/Suppl_1/A96-b</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1351-0711</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Objectives Tetrafluoroethylene (TFE), a compound used for the production of fluorinated polymers including polytetrafluoroethylene (PTFE), increases liver and kidney cancer and leukaemia incidence in rats and mice. This is the first time the cancer risk in humans is comprehensively explored in a cohort mortality study. Methods The study included all current PTFE production sites in Europe (Germany, Italy, The Netherlands and UK) and USA (New Jersey and West Virginia). The study cohort included workers ever employed in the period 1950–2002. A job-exposure matrix (1950–2002) was developed for TFE and ammonium perfluoro-octanoate (APFO), a chemical used in the polymerisation process. For each worker we calculated cumulative exposure to TFE and APFO. The mortality ascertainment covered the period 1950–2008. Standardised mortality ratios (SMR) and 95% confidence intervals (CI) were calculated using national mortality rates as reference. Results Among 4,773 workers ever exposed to TFE, we found lower SMRs from most causes of death and increased SMRs for cancer of the liver (SMR 1.27; 95% CI: 0.55, 2.51; 8 deaths) and kidney (SMR 1.44; 95% CI: 0.69, 2.65; 10 deaths), and for leukaemia (SMR 1.48; 95% CI: 0.77, 2.59; 12 deaths). A non-significant upward trend (P = 0.24) by cumulative exposure to TFE was observed for liver cancer. TFE and APFO exposures were highly correlated, therefore their separate effects could not be disentangled. Conclusions The pattern of findings in this large study substantially narrows the range of uncertainty on the possible cancer risk entailed by working in TFE synthesis and polymerisation, and justifies continuing efforts to minimise exposure, which has already dropped considerably over the years. However, the findings could neither conclusively confirm nor refute the hypothesis that TFE poses a carcinogenic risk to human beings. If a cancer hazard exists, then the risk is small, even in workers with relatively high exposure.</div></front></TEI><istex><corpusName>bmj</corpusName><author><json:item><name>D C Consonni</name><affiliations><json:string>Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, Italy</json:string></affiliations></json:item><json:item><name>Straif</name><affiliations><json:string>International Agency for Research on Cancer, Lyon, France</json:string></affiliations></json:item><json:item><name>Symons</name><affiliations><json:string>DuPont Epidemiology Program, E. I. du Pont de Nemours and Company, Newark, DE, United States of America</json:string></affiliations></json:item><json:item><name>Tomenson</name><affiliations><json:string>Causation Ltd, Macclesfield, United Kingdom</json:string></affiliations></json:item><json:item><name>Amelsvoort Van</name><affiliations><json:string>University of Maastricht, CAPHRI, Maastricht, The Netherlands</json:string></affiliations></json:item><json:item><name>Sleeuwenhoek</name><affiliations><json:string>Institute of Occupational Medicine, Edinburgh, United Kingdom</json:string></affiliations></json:item><json:item><name>Cherrie</name><affiliations><json:string>Institute of Occupational Medicine, Edinburgh, United Kingdom</json:string></affiliations></json:item><json:item><name>Bonetti</name><affiliations><json:string>Solvay Specialty Polymers Italy SpA, Bollate, Italy</json:string></affiliations></json:item><json:item><name>Colombo</name><affiliations><json:string>Solvay Specialty Polymers Italy SpA, Bollate, Italy</json:string></affiliations></json:item><json:item><name>Farrar</name><affiliations><json:string>CCERT Ltd for Asahi Glass Company Chemicals Europe (AGCCE), Congleton, United Kingdom</json:string></affiliations></json:item><json:item><name>Carugno</name><affiliations><json:string>DISCCO, Università degli Studi di Milano, Milano, Italy</json:string></affiliations></json:item><json:item><name>Bertazzi</name><affiliations><json:string>DISCCO, Università degli Studi di Milano, Milano, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Session: 12. Late breaking abstracts</value></json:item></subject><language><json:string>eng</json:string></language><abstract>Objectives Tetrafluoroethylene (TFE), a compound used for the production of fluorinated polymers including polytetrafluoroethylene (PTFE), increases liver and kidney cancer and leukaemia incidence in rats and mice. This is the first time the cancer risk in humans is comprehensively explored in a cohort mortality study. Methods The study included all current PTFE production sites in Europe (Germany, Italy, The Netherlands and UK) and USA (New Jersey and West Virginia). The study cohort included workers ever employed in the period 1950–2002. A job-exposure matrix (1950–2002) was developed for TFE and ammonium perfluoro-octanoate (APFO), a chemical used in the polymerisation process. For each worker we calculated cumulative exposure to TFE and APFO. The mortality ascertainment covered the period 1950–2008. Standardised mortality ratios (SMR) and 95% confidence intervals (CI) were calculated using national mortality rates as reference. Results Among 4,773 workers ever exposed to TFE, we found lower SMRs from most causes of death and increased SMRs for cancer of the liver (SMR 1.27; 95% CI: 0.55, 2.51; 8 deaths) and kidney (SMR 1.44; 95% CI: 0.69, 2.65; 10 deaths), and for leukaemia (SMR 1.48; 95% CI: 0.77, 2.59; 12 deaths). A non-significant upward trend (P = 0.24) by cumulative exposure to TFE was observed for liver cancer. TFE and APFO exposures were highly correlated, therefore their separate effects could not be disentangled. Conclusions The pattern of findings in this large study substantially narrows the range of uncertainty on the possible cancer risk entailed by working in TFE synthesis and polymerisation, and justifies continuing efforts to minimise exposure, which has already dropped considerably over the years. However, the findings could neither conclusively confirm nor refute the hypothesis that TFE poses a carcinogenic risk to human beings. If a cancer hazard exists, then the risk is small, even in workers with relatively high exposure.</abstract><qualityIndicators><score>4.742</score><pdfVersion>1.3</pdfVersion><pdfPageSize>662.967 x 861.392 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>1</keywordCount><abstractCharCount>1980</abstractCharCount><pdfWordCount>1742</pdfWordCount><pdfCharCount>11438</pdfCharCount><pdfPageCount>2</pdfPageCount><abstractWordCount>300</abstractWordCount></qualityIndicators><title>284 Cancer risk among tetrafluoroethylene (TFE) synthesis and polymerisation workers</title><genre><json:string>abstract</json:string></genre><host><volume>70</volume><pages><first>A96</first></pages><issn><json:string>1351-0711</json:string></issn><issue>Suppl 1</issue><genre></genre><language><json:string>unknown</json:string></language><eissn><json:string>1470-7926</json:string></eissn><title>Occupational and Environmental Medicine</title></host><publicationDate>2013</publicationDate><copyrightDate>2013</copyrightDate><doi><json:string>10.1136/oemed-2013-101717.284</json:string></doi><id>A15CAF5069534A577266DC3F2E4F0284A12F47AB</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/A15CAF5069534A577266DC3F2E4F0284A12F47AB/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/A15CAF5069534A577266DC3F2E4F0284A12F47AB/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A15CAF5069534A577266DC3F2E4F0284A12F47AB/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">284 Cancer risk among tetrafluoroethylene (TFE) synthesis and polymerisation workers</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>BMJ Publishing Group Ltd</publisher><availability><p>BMJ</p></availability><date>2013</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">284 Cancer risk among tetrafluoroethylene (TFE) synthesis and polymerisation workers</title><author><persName><forename type="first">D C</forename><surname>Consonni</surname></persName><affiliation>Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, Italy</affiliation></author><author><persName><surname>Straif</surname></persName><affiliation>International Agency for Research on Cancer, Lyon, France</affiliation></author><author><persName><surname>Symons</surname></persName><affiliation>DuPont Epidemiology Program, E. I. du Pont de Nemours and Company, Newark, DE, United States of America</affiliation></author><author><persName><surname>Tomenson</surname></persName><affiliation>Causation Ltd, Macclesfield, United Kingdom</affiliation></author><author><persName><forename type="first">Amelsvoort</forename><surname>Van</surname></persName><affiliation>University of Maastricht, CAPHRI, Maastricht, The Netherlands</affiliation></author><author><persName><surname>Sleeuwenhoek</surname></persName><affiliation>Institute of Occupational Medicine, Edinburgh, United Kingdom</affiliation></author><author><persName><surname>Cherrie</surname></persName><affiliation>Institute of Occupational Medicine, Edinburgh, United Kingdom</affiliation></author><author><persName><surname>Bonetti</surname></persName><affiliation>Solvay Specialty Polymers Italy SpA, Bollate, Italy</affiliation></author><author><persName><surname>Colombo</surname></persName><affiliation>Solvay Specialty Polymers Italy SpA, Bollate, Italy</affiliation></author><author><persName><surname>Farrar</surname></persName><affiliation>CCERT Ltd for Asahi Glass Company Chemicals Europe (AGCCE), Congleton, United Kingdom</affiliation></author><author><persName><surname>Carugno</surname></persName><affiliation>DISCCO, Università degli Studi di Milano, Milano, Italy</affiliation></author><author><persName><surname>Bertazzi</surname></persName><affiliation>DISCCO, Università degli Studi di Milano, Milano, Italy</affiliation></author></analytic><monogr><title level="j">Occupational and Environmental Medicine</title><title level="j" type="abbrev">Occup Environ Med</title><idno type="pISSN">1351-0711</idno><idno type="eISSN">1470-7926</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="2013-09"></date><biblScope unit="volume">70</biblScope><biblScope unit="issue">Suppl 1</biblScope><biblScope unit="page" from="A96">A96</biblScope></imprint></monogr><idno type="istex">A15CAF5069534A577266DC3F2E4F0284A12F47AB</idno><idno type="DOI">10.1136/oemed-2013-101717.284</idno><idno type="href">oemed-70-A96-3.pdf</idno><idno type="ArticleID">oemed-2013-101717.284</idno><idno type="local">oemed;70/Suppl_1/A96-b</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2013</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Objectives Tetrafluoroethylene (TFE), a compound used for the production of fluorinated polymers including polytetrafluoroethylene (PTFE), increases liver and kidney cancer and leukaemia incidence in rats and mice. This is the first time the cancer risk in humans is comprehensively explored in a cohort mortality study. Methods The study included all current PTFE production sites in Europe (Germany, Italy, The Netherlands and UK) and USA (New Jersey and West Virginia). The study cohort included workers ever employed in the period 1950–2002. A job-exposure matrix (1950–2002) was developed for TFE and ammonium perfluoro-octanoate (APFO), a chemical used in the polymerisation process. For each worker we calculated cumulative exposure to TFE and APFO. The mortality ascertainment covered the period 1950–2008. Standardised mortality ratios (SMR) and 95% confidence intervals (CI) were calculated using national mortality rates as reference. Results Among 4,773 workers ever exposed to TFE, we found lower SMRs from most causes of death and increased SMRs for cancer of the liver (SMR 1.27; 95% CI: 0.55, 2.51; 8 deaths) and kidney (SMR 1.44; 95% CI: 0.69, 2.65; 10 deaths), and for leukaemia (SMR 1.48; 95% CI: 0.77, 2.59; 12 deaths). A non-significant upward trend (P = 0.24) by cumulative exposure to TFE was observed for liver cancer. TFE and APFO exposures were highly correlated, therefore their separate effects could not be disentangled. Conclusions The pattern of findings in this large study substantially narrows the range of uncertainty on the possible cancer risk entailed by working in TFE synthesis and polymerisation, and justifies continuing efforts to minimise exposure, which has already dropped considerably over the years. However, the findings could neither conclusively confirm nor refute the hypothesis that TFE poses a carcinogenic risk to human beings. If a cancer hazard exists, then the risk is small, even in workers with relatively high exposure.</p></abstract></profileDesc><revisionDesc><change when="2013-09">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/A15CAF5069534A577266DC3F2E4F0284A12F47AB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus bmj" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="no"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Archiving and Interchange DTD v2.3 20070202//EN" URI="archivearticle.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="abstract" xml:lang="EN"><front><journal-meta><journal-id journal-id-type="hwp">oemed</journal-id><journal-id journal-id-type="nlm-ta">Occup Environ Med</journal-id><journal-id journal-id-type="publisher-id">oemed</journal-id><journal-title>Occupational and Environmental Medicine</journal-title><abbrev-journal-title abbrev-type="publisher">Occup Environ Med</abbrev-journal-title><abbrev-journal-title>Occup Environ Med</abbrev-journal-title><issn pub-type="ppub">1351-0711</issn><issn pub-type="epub">1470-7926</issn><publisher><publisher-name>BMJ Publishing Group Ltd</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">oemed-2013-101717.284</article-id><article-id pub-id-type="doi">10.1136/oemed-2013-101717.284</article-id><article-id pub-id-type="other">oemed;70/Suppl_1/A96-b</article-id><article-id pub-id-type="other">oemed;oemed-2013-101717.284</article-id><article-id pub-id-type="other">A96.3</article-id><article-id pub-id-type="other">oemed-2013-101717.284</article-id><article-categories><subj-group subj-group-type="heading"><subject>Session: 12. Late breaking abstracts</subject></subj-group></article-categories><title-group><article-title>284 Cancer risk among tetrafluoroethylene (TFE) synthesis and polymerisation workers</article-title></title-group><contrib-group><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Consonni</surname><given-names>D C</given-names></name><xref ref-type="aff" rid="AF0001"><sup>1</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Straif</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0002"><sup>2</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Symons</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0003"><sup>3</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Tomenson</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0004"><sup>4</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Van</surname><given-names>Amelsvoort</given-names></name><xref ref-type="aff" rid="AF0005"><sup>5</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Sleeuwenhoek</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0006"><sup>6</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Cherrie</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0006"><sup>6</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Bonetti</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0007"><sup>7</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Colombo</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0007"><sup>7</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Farrar</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0008"><sup>8</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Carugno</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0009"><sup>9</sup></xref></contrib><contrib contrib-type="author" xlink:type="simple"><name name-style="western"><surname>Bertazzi</surname><given-names></given-names></name><xref ref-type="aff" rid="AF0009"><sup>9</sup></xref></contrib></contrib-group><aff id="AF0001"><sup>1</sup>Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, Italy</aff><aff id="AF0002"><sup>2</sup>International Agency for Research on Cancer, Lyon, France</aff><aff id="AF0003"><sup>3</sup>DuPont Epidemiology Program, E. I. du Pont de Nemours and Company, Newark, DE, United States of America</aff><aff id="AF0004"><sup>4</sup>Causation Ltd, Macclesfield, United Kingdom</aff><aff id="AF0005"><sup>5</sup>University of Maastricht, CAPHRI, Maastricht, The Netherlands</aff><aff id="AF0006"><sup>6</sup>Institute of Occupational Medicine, Edinburgh, United Kingdom</aff><aff id="AF0007"><sup>7</sup>Solvay Specialty Polymers Italy SpA, Bollate, Italy</aff><aff id="AF0008"><sup>8</sup>CCERT Ltd for Asahi Glass Company Chemicals Europe (AGCCE), Congleton, United Kingdom</aff><aff id="AF0009"><sup>9</sup>DISCCO, Università degli Studi di Milano, Milano, Italy</aff><pub-date pub-type="ppub"><month>09</month><year>2013</year></pub-date><volume>70</volume><volume-id pub-id-type="other">70</volume-id><volume-id pub-id-type="other">70</volume-id><issue>Suppl 1</issue><issue-id pub-id-type="other">oemed;70/Suppl_1</issue-id><issue-id pub-id-type="other" content-type="supplement">Suppl_1</issue-id><issue-id pub-id-type="other">70/Suppl_1</issue-id><issue-title>23rd Conference on Epidemiology in Occupational Health EPICOH 2013: Improving the Impact June 18–21, 2013, Utrecht, The Netherlands</issue-title><fpage seq="3">A96</fpage><permissions><copyright-statement>© 2013, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</copyright-statement><copyright-year>2013</copyright-year></permissions><self-uri content-type="pdf" xlink:role="full-text" xlink:href="oemed-70-A96-3.pdf"></self-uri><abstract><sec><title>Objectives</title><p>Tetrafluoroethylene (TFE), a compound used for the production of fluorinated polymers including polytetrafluoroethylene (PTFE), increases liver and kidney cancer and leukaemia incidence in rats and mice. This is the first time the cancer risk in humans is comprehensively explored in a cohort mortality study.</p></sec><sec><title>Methods</title><p>The study included all current PTFE production sites in Europe (Germany, Italy, The Netherlands and UK) and USA (New Jersey and West Virginia). The study cohort included workers ever employed in the period 1950–2002. A job-exposure matrix (1950–2002) was developed for TFE and ammonium perfluoro-octanoate (APFO), a chemical used in the polymerisation process. For each worker we calculated cumulative exposure to TFE and APFO. The mortality ascertainment covered the period 1950–2008. Standardised mortality ratios (SMR) and 95% confidence intervals (CI) were calculated using national mortality rates as reference.</p></sec><sec><title>Results</title><p>Among 4,773 workers ever exposed to TFE, we found lower SMRs from most causes of death and increased SMRs for cancer of the liver (SMR 1.27; 95% CI: 0.55, 2.51; 8 deaths) and kidney (SMR 1.44; 95% CI: 0.69, 2.65; 10 deaths), and for leukaemia (SMR 1.48; 95% CI: 0.77, 2.59; 12 deaths). A non-significant upward trend (P = 0.24) by cumulative exposure to TFE was observed for liver cancer. TFE and APFO exposures were highly correlated, therefore their separate effects could not be disentangled.</p></sec><sec><title>Conclusions</title><p>The pattern of findings in this large study substantially narrows the range of uncertainty on the possible cancer risk entailed by working in TFE synthesis and polymerisation, and justifies continuing efforts to minimise exposure, which has already dropped considerably over the years. However, the findings could neither conclusively confirm nor refute the hypothesis that TFE poses a carcinogenic risk to human beings. If a cancer hazard exists, then the risk is small, even in workers with relatively high exposure.</p></sec></abstract></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>284 Cancer risk among tetrafluoroethylene (TFE) synthesis and polymerisation workers</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>284 Cancer risk among tetrafluoroethylene (TFE) synthesis and polymerisation workers</title></titleInfo><name type="personal"><namePart type="given">D C</namePart><namePart type="family">Consonni</namePart><affiliation>Fondazione IRCCS Ca’ Granda - Ospedale Maggiore Policlinico, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Straif</namePart><affiliation>International Agency for Research on Cancer, Lyon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Symons</namePart><affiliation>DuPont Epidemiology Program, E. I. du Pont de Nemours and Company, Newark, DE, United States of America</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Tomenson</namePart><affiliation>Causation Ltd, Macclesfield, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Amelsvoort</namePart><namePart type="family">Van</namePart><affiliation>University of Maastricht, CAPHRI, Maastricht, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Sleeuwenhoek</namePart><affiliation>Institute of Occupational Medicine, Edinburgh, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Cherrie</namePart><affiliation>Institute of Occupational Medicine, Edinburgh, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Bonetti</namePart><affiliation>Solvay Specialty Polymers Italy SpA, Bollate, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Colombo</namePart><affiliation>Solvay Specialty Polymers Italy SpA, Bollate, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Farrar</namePart><affiliation>CCERT Ltd for Asahi Glass Company Chemicals Europe (AGCCE), Congleton, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Carugno</namePart><affiliation>DISCCO, Università degli Studi di Milano, Milano, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="family">Bertazzi</namePart><affiliation>DISCCO, Università degli Studi di Milano, Milano, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="abstract" displayLabel="abstract"></genre><originInfo><publisher>BMJ Publishing Group Ltd</publisher><dateIssued encoding="w3cdtf">2013-09</dateIssued><copyrightDate encoding="w3cdtf">2013</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Objectives Tetrafluoroethylene (TFE), a compound used for the production of fluorinated polymers including polytetrafluoroethylene (PTFE), increases liver and kidney cancer and leukaemia incidence in rats and mice. This is the first time the cancer risk in humans is comprehensively explored in a cohort mortality study. Methods The study included all current PTFE production sites in Europe (Germany, Italy, The Netherlands and UK) and USA (New Jersey and West Virginia). The study cohort included workers ever employed in the period 1950–2002. A job-exposure matrix (1950–2002) was developed for TFE and ammonium perfluoro-octanoate (APFO), a chemical used in the polymerisation process. For each worker we calculated cumulative exposure to TFE and APFO. The mortality ascertainment covered the period 1950–2008. Standardised mortality ratios (SMR) and 95% confidence intervals (CI) were calculated using national mortality rates as reference. Results Among 4,773 workers ever exposed to TFE, we found lower SMRs from most causes of death and increased SMRs for cancer of the liver (SMR 1.27; 95% CI: 0.55, 2.51; 8 deaths) and kidney (SMR 1.44; 95% CI: 0.69, 2.65; 10 deaths), and for leukaemia (SMR 1.48; 95% CI: 0.77, 2.59; 12 deaths). A non-significant upward trend (P = 0.24) by cumulative exposure to TFE was observed for liver cancer. TFE and APFO exposures were highly correlated, therefore their separate effects could not be disentangled. Conclusions The pattern of findings in this large study substantially narrows the range of uncertainty on the possible cancer risk entailed by working in TFE synthesis and polymerisation, and justifies continuing efforts to minimise exposure, which has already dropped considerably over the years. However, the findings could neither conclusively confirm nor refute the hypothesis that TFE poses a carcinogenic risk to human beings. If a cancer hazard exists, then the risk is small, even in workers with relatively high exposure.</abstract><relatedItem type="host"><titleInfo><title>Occupational and Environmental Medicine</title></titleInfo><titleInfo type="abbreviated"><title>Occup Environ Med</title></titleInfo><genre type="Journal">journal</genre><identifier type="ISSN">1351-0711</identifier><identifier type="eISSN">1470-7926</identifier><identifier type="PublisherID">oemed</identifier><identifier type="PublisherID-hwp">oemed</identifier><identifier type="PublisherID-nlm-ta">Occup Environ Med</identifier><part><date>2013</date><detail type="title"><title>23rd Conference on Epidemiology in Occupational Health EPICOH 2013: Improving the Impact June 18–21, 2013, Utrecht, The Netherlands</title></detail><detail type="volume"><caption>vol.</caption><number>70</number></detail><detail type="issue"><caption>no.</caption><number>Suppl 1</number></detail><extent unit="pages"><start>A96</start></extent></part></relatedItem><identifier type="istex">A15CAF5069534A577266DC3F2E4F0284A12F47AB</identifier><identifier type="DOI">10.1136/oemed-2013-101717.284</identifier><identifier type="href">oemed-70-A96-3.pdf</identifier><identifier type="ArticleID">oemed-2013-101717.284</identifier><identifier type="local">oemed;70/Suppl_1/A96-b</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2013, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</accessCondition><recordInfo><recordContentSource>BMJ</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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